Modeling Neurodegeneration in Zebrafish
نویسندگان
چکیده
منابع مشابه
Modeling Neurodegeneration in Zebrafish
The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the study of developmental biology and gene function. It also has proven to be a valuable model to study human diseases. Here, we reviewed recent publications using zebrafish to study the pathology of human neurodegenerative diseases including Parkinson's, Huntington's, and Alzheimer's. These studies indicate ...
متن کاملModeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain.
Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, neuronal death, and learning deficits. Humans cannot regenerate lost neurons in the case of AD in part due to impaired proliferative capacity of the neural stem/progenitor cells (NSPCs) and reduced neurogenesis. Therefore, ...
متن کاملMitophagy and neurodegeneration: the zebrafish model system.
Autophagy is responsible for the degradation of cytoplasmic components and organelles such as mitochondria. The selective degradation of damaged mitochondria by autophagy is termed mitophagy, and is an important quality control mechanism. Neurons, being highly specialized cells, are particularly susceptible to defects of autophagy. Impairments in mitochondrial function and their dynamics are pr...
متن کاملNeurodegeneration in zebrafish embryos and adults after cadmium exposure
Cadmium is a biologically non-essential metal. It is also toxic to many organs including the brain. The aim of this study was to analyse the neurodegenerative effects of this metal in embryos and adults of zebrafish exposed to sub-lethal concentrations of cadmium. The study was performed by cytochemical stainings. Six hours after fertilisation (hpf) zebrafish embryos were treated for 24 hours w...
متن کاملModeling Tumor Angiogenesis in Zebrafish
The process of angiogenesis is essential for tumor progression and metastasis. New pathways have been identified to play a critical role in promoting and regulating blood vessel formation both in embryogenesis and in pathophysiological conditions. These pathways provide potential molecular targets for anti-angiogenic therapies to treat cancer and other vascular diseases. The critical cellular t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Neurology and Neuroscience Reports
سال: 2011
ISSN: 1528-4042,1534-6293
DOI: 10.1007/s11910-011-0182-2